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Matching Question Set 1: Antifungals
Matching exercise
Pick the best match from the options (down arrow)
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fluconazole
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
itraconazole
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
griseofulvin
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
terbinafine
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
flucytosine
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
ketoconazole
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
amphotericin B
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
nystatin
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
naftifine
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
miconazole
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fungicidal;inhibits squalene epoxidase;dermatophytoses- onychomycosis;
derived from Penicillum; systemic dermatophytosis treatment
topical polyene macrolide activity:most Candida species;
most potent of available azoles
gynecomastia and menstrual irregularities
broadest spectrum of action
allylamine available as a topical cream - tinea cruris
topical azole; vulvovaginal candidiasis
azole with highest CSF:Serum ratio
cryptococcus neoformans; no monotherapy-resistance
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Antifungal Pharmacology